IFNA1 and infection: Additionally, infection of mice deficient in IFN receptors (Ifnar1, Ifngr1, Ifnlr1; single or double knockouts) with enteric viruses indicates that IFN-λ is the predominant antiviral IFN type that controls viral replication in the gastrointestinal epithelium (Hernández et al., 2015; Nice et al., 2015; Pott et al., 2011).