We assessed an earlier timepoint at 12 hr post-inoculation and observed similar trends toward an increased proportion of IEC infection in Ifnlr1 IEC-cKO relative to Ifnlr1flox/flox littermates, but the extent of infection was 10- to 100-fold lower and near the limit of detection (Figure 9—figure supplement 1). Here, IFNLR1 is linked to infection.