Current data had concluded that MSC/miR-374a-5p-Exo markedly inhibited TGF-β1-induced apoptosis of HK-2 cells and prevented the progression of renal fibrosis in vivo by regulating MAPK6/MK5/YAP axis, suggesting that MAPK6/MK5/YAP was vital in the pathogenesis of renal fibrosis. This evidence concerns the gene MAPK6 and renal fibrosis.