SNCA and Parkinson disease: It was concluded that compared to the Sham group, 6-OHDA-induced PD mice had up-regulated MIR17HG (P < 0.001, Figure 2b) and down-regulated miR-153-3p (P < 0.001, Figure 2c), accompanied by enhanced mRNA and protein expression of SNCA (P < 0.001, Figure 2d, e).