We also investigated the abundance of circCHFR, miR-15b-5p, and GADD45G in ox-LDL-treated HUVECs and their involvement in atherosclerosis, as well as the mechanism by which circCHFR contributes to atherosclerosis development via the miR-15b-5p/GADD45G axis. The gene discussed is GADD45G; the disease is atherosclerosis.