Peng et al. depicted that higher expression of methylation of Sodium Channel Epithelial 1 Beta Subunit (SCNN1B), nuclear factor, erythroid 2-like 3 (NFE2L3) and Claudin 2 (CLDN2), RNA-binding protein for multiple splicing 2 (RBPMS2) was associated with unfavorable prognosis of GC patients [15]. The gene discussed is CLDN2; the disease is gastric cancer.