In clinical studies of human patients affected by periodontitis, the laminin 5γ chain was highly expressed in the gingival crevicular fluid sampled at sites with deep periodontal pockets [30] Therefore, our data suggest that Laminin 5-mediated remodeling of the epithelial cells that comprise the dentogingival junction is enhanced by TNF-α. The gene discussed is TNF; the disease is periodontitis.