Previous studies have shown that the downregulation of TUSC3 expression is tightly associated with the incidence of several human cancer types, including hepatocellular carcinoma, breast cancer, pancreatic cancer and ovarian cancer,10, 11, 12, 13 suggesting a functional association between the downregulation of TUSC3 expression and cancer progression. Here, TUSC3 is linked to pancreatic neoplasm.