It has been shown that the AKT signalling pathway exhibits a significant impact on cancer progression by regulating cell growth,20, 21, 27 cell apoptosis and mesenchymal transition.10, 11, 28, 29, 30, 31 It had been verified that TUSC3 could active many important pathways, including PI3K/AKT/mTOR (PI3K/AKT) and Ras‐MEK‐ERK (MAPKs), were related to the regulation of MMP9.32 Here, TUSC3 is linked to cancer.