In this study, we performed exome sequencing and targeted resequencing of 2462 people with severe obesity and identified 23 rare heterozygous variants in SRC-1 (Fig. 1B); a number of variants were found in multiple unrelated individuals and some were present in publicly available exomes (Table 1). The gene discussed is NCOA1; the disease is obesity due to melanocortin 4 receptor deficiency.