Among over 900 TFs and epigenetic modulators, YBX1 (Y-box binding protein 1) and REST (RE1 silencing transcription factor) were the top two predicted TFs, and both have been implicated in breast cancer progression (36,37) Interestingly, several PRC2 subunits including EED, EZH2, SUZ12 and JARID2 were identified among the top hits. The gene discussed is EZH2; the disease is breast cancer.