KRI-1 acts via the conserved adaptors ICAP-1 and CCM-2, which, like KRI-1, are linked to cerebral cavernous malformation by curtailing the activity of the ERK-5 MAP kinase pathway, the overactivation of which inhibits KLF-3 (Chapman et al. 2019). The gene discussed is KRI1; the disease is famililal cerebral cavernous malformations.