Utilizing serially assessed hsTnT and NT-proBNP improves the ABC stroke risk score and the same holds for GDF-15 incorporated in the ABC bleeding risk score.44 Although this paper supports the notion that serial biomarkers may better reflect the risk of adverse events in AF,21 it may not immediately change practice: what if NT-proBNP and hsTnT increased in an already anticoagulated patient? The gene discussed is NPPB; the disease is stroke disorder.