Importantly, non-LOF SCN5A variation carriers (n = 15) exhibited no LAEs during the follow-up period.53 Multivariate analysis demonstrated that only LOF SCN5A mutations and a history of aborted cardiac arrest were significant predictors of LAEs.53 Rare variations of non-SCN5A BrS-associated genes did not affect LAE-free survival curves. Here, SCN5A is linked to cardiac arrest.