In the pathway of central carbon metabolism in cancer, SIRT6 could directly inhibit hypoxia-inducible factor 1α (HIF-1α), and SIRT3 could inhibit HIF-1α by repressing HIF-1 signaling, which then affected metabolic process such as glycolysis and tricarboxylic acid (TCA) cycle (Figure 8). Here, HIF1A is linked to cancer.