It can significantly reduce the cerebral infarction volume of rats with cerebral I/R injury, improve brain edema, enhance the antioxidant activity of SOD, GSH-Px, and T-AOC, reduce MDA lipid peroxidation damage and inhibit the apoptosis of I/R rat brain cells and alleviate brain I/R injury through suppressing TLR4/NF-κB signaling. This evidence concerns the gene SOD1 and brain infarction.