In triple-negative breast cancer (TNBC) cellular models, the E3 ligase RING finger protein 181 (RNF181) ubiquitylates and stabilizes YAP, the key effector of the Hippo signaling pathway, potentially protecting it from K48 linked proteolytic ubiquitylation events mediated by the E3 ligases FBW7 and SCF120 (Fig. 4). Here, RNF181 is linked to triple-negative breast carcinoma.