Considering that all above-mentioned components (USP32, Parkin, Rab7), as well as deregulation of endosomal membrane dynamics have been implicated in the pathogenesis of Parkinson’s disease (PD), we could speculate that non-proteolytic ubiquitylation signaling within the endolysosomal system might provide new perspectives into the development of therapeutic strategies against PD. The gene discussed is PRKN; the disease is Parkinson disease.