Within the context of targeting non-proteolytic ubiquitylation of TRKs in cancer, a recent study on the epidermal growth factor receptor (EGFR) revealed the involvement of the RING E3 ligase CBLC in sustaining an hyperactive EGFR signaling in lung adenocarcinoma both in vitro and in vivo39 (Fig. 4). This evidence concerns the gene EGFR and lung adenocarcinoma.