However, since patients with co-morbidities such as CAD, hypertension, diabetes, hyperlipidaemia were excluded from our study to avoid interfering with the research purposes, the role of adiponectin in metabolic disorder in our cohort is unclear and further analysis in real-world RA patients is warranted so as to explore the function of adiponectin in the setting of inflammation and metabolic disorder. This evidence concerns the gene ADIPOQ and hypertensive disorder.