To substantiate the efficacy of genetic PHLPP1 inhibition seen in our recent study [2] in a severe in vivo mouse model of hyperglycemia and obesity-associated diabetes progression, we have deleted PHLPP1 in leptin receptor-deficient Leprdb/db (db/db) mice. The gene discussed is PHLPP1; the disease is obesity due to melanocortin 4 receptor deficiency.