In female mice, hyperglycemia (>10 mM; Fig. 5f) resulted in mildly elevated insulin secretion in βInsrKO relative to control mice for the initial 48 h, which was not sustained for the duration of the experiment (Fig. 5g, h), while glucagon levels declined similarly in both genotypes (Fig. 5i, j). This evidence concerns the gene INS and Hyperglycemia.