Moreover, syndecan-2 is reported to attenuate radiation-induced pulmonary fibrosis in mice and inhibit TGF-β1-induced fibroblast-myofibroblast differentiation, migration, and proliferation by down-regulating phosphoinositide 3-kinase/serine/threonine kinase/Rho-associated coiled-coil kinase signaling and blocking serum response factor binding to the α-SMA promoter via CD148 [29]. Here, ACTA1 is linked to pulmonary fibrosis.