SDCBP and cancer: To assess the involvement of syntenin-1-mediated sEVs in cancer progression, we prepared sEVs from syntenin-1-knockdown cancer cell lines, such as NCI-H226, NCI-H1975, A549, HCC827, and MCF7 cells, and further evaluated their effects on the migration of A549 cells (Fig. 3B–F).