PPARG and cancer: Furthermore, miR-494-3p regulates mitochondrial biogenesis and thermogenesis in beige adipocytes by targeting PPARγ coactivator1-α [32]; however, the detailed role of miR-494-3p in lung cancer progression, particularly in sEV-mediated intercellular communication during cancer progression in the TME, as well as the molecular mechanisms by which miR-494-3p regulates cancer progression in the TME, remain unclear.