In the present study, we demonstrated that oncogenic Ras/syntenin-1 axis stimulates the release of sEVs and loading of onco-miRNAs, including miR-494-3p, into sEVs to promote the growth, migration, and metastasis of human lung cancer cells as well as tumor angiogenesis by targeting PTPN12; however, the suppression of oncogenic Ras or syntenin-1 inhibited these sEV-mediated effects (Fig. 8K). Here, PTPN12 is linked to lung cancer.