In addition, knockdown of syntenin-1 reduced the oncogenic Ras-mediated release of sEVs and expression levels of these miRNAs in sEVs, thereby suggesting that syntenin-1 could act as one of the Ras signaling effectors for modulating the biogenesis and secretion of sEVs as well as for loading of specific onco-miRNAs, including miR-494-3p, into sEVs in order to induce tumor progression in the TME. The gene discussed is SDCBP; the disease is neoplasm.