Its expression has been found to be correlated with lung cancer progression in a K-Ras knock-in mouse model and with worse survival in lung cancer patients; moreover, it enhances the malignant progression of lung cancer cells by targeting phosphatase and tensin homolog (PTEN)/phosphoinositide 3-kinase (PI3K)/AKT signaling [25, 26]. The gene discussed is PTEN; the disease is lung cancer.