MST1 is not only activated in β-cells under diabetogenic conditions of lipo- and glucotoxicity [1], but also in insulin target tissues, shown in epididymal fat of high fat diet-treated mice [12] as well as in rodent cardiomyocytes [13] and podocytes [14] under high glucose conditions and in the kidney of hyperglycemic IRS2-KO mice [15], indicating its disease-relevant upregulation in several organs during diabetes progression. Here, INS is linked to diabetes mellitus.