Inhibition of miR-10b-5p using an antagomir (AM-10b-5p) in GBM neurospheres increased TET2 mRNA without affecting TET1 gene expression (Fig. 4c and Supplementary Fig. 11b) and concurrently increased 5hmC and decreased 5mC levels (Fig. 4d). Here, TET1 is linked to glioblastoma.