TET2 and glioblastoma: Inhibition of miR-10b-5p using an antagomir (AM-10b-5p) in GBM neurospheres increased TET2 mRNA without affecting TET1 gene expression (Fig. 4c and Supplementary Fig. 11b) and concurrently increased 5hmC and decreased 5mC levels (Fig. 4d).