GSC frequency and self-renewal capacity predict tumor growth capacity in vivo.28 To examine if TET2 inhibition affects the growth of GBM xenografts, the neurosphere lines described above were implanted to caudate-putamen of immune-deficient mice and all animals were sacrificed when the group implanted with TET2 knockdown cells began to show adverse signs of tumor burden. This evidence concerns the gene TET2 and neoplasm.