TET2 and glioblastoma: PBAE-nanoparticle-based delivery of AM-10b-5p nano-miRs to GBM neurospheres in vitro significantly decreased levels of endogenous miR-10b-5p by ~70%, significantly increased TET2 mRNA and 5hmC levels, and inhibited GBM neurosphere cell growth and self-renewal as spheres without affecting cell viability, recapitulating results using the lentiviral based AM-10b-5p delivery (Supplementary Fig. 13).