MicroRNAs regulate multiple biological processes including epigenetics and tumorigenesis29 and have been found to contribute to TET2 dysregulation and hematopoietic stem cell transformation.30 We have reported that OCT4 and SOX2 regulate a focused panel of miRNAs that impact GBM cell stemness and malignancy via multiple mechanisms involving DNMTs and regulators of chromatin architecture.21,31 Using these previously validated approaches for identifying GSC-regulating miRNAs, we asked if SOX2 activates onco-miRs that repress TET2 expression and thereby regulate GSCs. The gene discussed is SOX2; the disease is glioblastoma.