Our findings are consistent with research showing that miR-10b-5p expression is a strong marker of poor prognosis for GBM and can regulate the tumor and stem cell phenotype of GBM cells.39,45,46 These results demonstrate that the SOX2:miR-10b-5p:TET2 axis acts as a critical mediator of onco-methylation in GSCs and highlights a new putative mechanism of 5hmC reduction in GBM. Here, SOX2 is linked to neoplasm.