Additionally, PTBP3 expression was detected in 5 human CRC cell lines (HT-29, HCT116, SW480, SW620 and LoVo) and normal human colonic epithelial FHC cells, and PTBP3 expression was significantly higher in cancer cell lines than in FHC cells (Fig. 1E, F). The gene discussed is PTBP3; the disease is cancer.