Consistently, RORα/RORγ ligands (i.e. SR1001) have been reported to suppress the differentiation of T-helper cells that produce interleukin-17 (Th17 cells), crucial effector cells implicated in the pathology of numerous autoimmune diseases, and to reduce cytokines expression, thereby alleviating autoimmune disease symptoms in animal models of multiple sclerosis139. This evidence concerns the gene RORC and autoimmune disease.