As an example, Wang et al. demonstrated that, in mice with dextran sodium sulfate (DSS)-induced colitis, colonic inflammation was associated with the dysregulation of clock genes (i.e. NR1D1/REV-ERBα, CLOCK, BMALl1, PER2, CRY1, NPAS2, NR1D2/REV-ERBβ, RORα, and DBP) expression68. This evidence concerns the gene NR1D1 and colitis.