We studied 500 control and 500 HCC patients and found that the GG genotype at stat4 rs7574865 was a risk genotype for HCC, and the STAT4 protein content in serum and livers of GG carriers was significantly higher than the STAT4 content in the serum and livers of TG and TT carriers. This evidence concerns the gene STAT4 and hepatocellular carcinoma.