CLIC1 and neoplasm: However, we have to point out that, not only low CLIC1-expressing GSCs were isolated from patients which developed aggressive GBMs, but also that GBM39 cells retain tumorigenic potential in vivo, similar to high CLIC1-expressing GSCs (mean survival time of orthotopically xenografted mice was 100 days for GBM39 and GBM23, and 120 days for GBM3, Table S1), suggesting that this protein is dispensable for tumor development and progression in vivo.