Thus, while CLIC1 functional expression enhances GSC proliferation and tumorigenesis, its activity can be circumvented in some GBMs through the activation of alternative intracellular pathways allowing tumor development and progression also when the channel activity is negligible, as also shown by the lack of differences in patients’ survival according to CLIC1 expression (see Fig. S12). Here, CLIC1 is linked to neoplasm.