Elevated mRNA expression of MTHFD2 was identified in various human tumors, including Brain and CNS Cancer, Breast Cancer, Cervical Cancer, Colorectal Cancer, Esophageal Cancer, Head and Neck Cancer, Kidndy Cancer, Leukemia, Liver Cancer, Lung Cancer, Lymphoma, Ovarian Cancer, Prostate Cancer, and Sarcoma (Fig. 2A). This evidence concerns the gene MTHFD2 and lung carcinoma.