Therefore, in this study, we utilized CODEX multiplexed imaging technique, which helps us to explore the functional significance of targeting the S100A7/cPLA2 signaling axis on abundance, cell surface expression, and interactions of different subsets of CD4+ and CD8+ TILs by using our tumor-bearing MMTV-mS100a7a15, a bi-transgenic mouse model. The gene discussed is CD8A; the disease is neoplasm.