This study demonstrated the selective uptake of the particles into the endothelium and the inhibition of atherosclerosis in vivo using a traditional ApoE−/− murine atherosclerosis model [62].It is worth noting that anti-miR-712 was only internalized by the surface endothelial cells and was not further transported into the vessel wall, which might indicate that the NPs are too large to travel through the endothelial layer. Here, APOE is linked to atherosclerosis.