When comparing the Peds-QL NF1 module scores, women had significantly lower total scores, indicating worse QoL; they also had lower scores in the emotion, perceived physical appearance and anxiety domains; the most significant difference was in the perceived physical appearance domain (41.4 ± 31.2 and 64.3 ± 30.6, p < 0.0001, Table 2). This evidence concerns the gene NF1 and Anxiety.