IDH2 and diffuse astrocytoma: Other markers in CNS5 are merely related to grade and further estimate prognosis, such as CDKN2A/B homozygous deletion in IDH-mutant astrocytoma, as well as 1p/19q co-deleted, TERT promoter mutation, EGFR amplification or mutation, and + 7/ − 10 copy number changes in IDH-wildtype diffuse astrocytoma [2].