EGFR and glioblastoma: Depatuxizumab (formerly ABT-806) showed limited efficacy, but Depatuxizumab mafodotin (formerly ABT-414), an antibody–drug conjugate using EGFR antibody as receptor-direction, seemed to be effective in recurrent GBM (rGBM) after standard treatment of TMZ [52, 53], but ineffective in newly-diagnosed GBM (NCT02573324) [54].