The cytokines that change in schizophrenia have similar changes in metabolic disorders, such as interleukin-1Rα(IL-1Rα), IL-1β, IL-2, IL-6, IL-10, interferon-γ(IFN-γ), tumor necrosis factor-α(TNF-α), and C-reactive protein (CRP) [12, 13]. This evidence concerns the gene TNF and Other metabolic disease.