Therefore, to better understand the relationship between these genes, we conducted a study that examined the distribution of SNPsof BIN1, STARD6, RIN3, APOE, PICALM, SPI1, BZRAP1-AS, PFDN1/HBEGF, TMP21, MTHFR, TMEM106B, MC1R, CENPO, PVRL2 and KL genes to reveal the correlation between the polymorphisms and AD risk. This evidence concerns the gene APOE and Alzheimer disease.