MYC and pancreatic neoplasm: Our results are in line with the literature describing the role of polyamines in pancreatic neoplasia and tumour growth.13 Pancreatic cancer progresses slowly from exocrine pancreatic cells from dysplasia to non-invasive precursor lesions and a malignant tumour.23, –25 Interestingly, the most important gene mutations related with the development of pancreatic cancer, that is, KRAS and MYC, are activators of polyamine metabolism.