Amyloid processing, neuroinflammation signaling pathway, axonal guidance signaling, role of NANOG in mammalian embryonic stem cell pluripotency, glioblastoma multiforme signaling, glioma invasiveness signaling, synaptogenesis signaling pathway, amyotrophic lateral sclerosis signaling, neuroprotective role of THOP1 in Alzheimer’s disease, TGF-β signaling, synaptic long-term potentiation, neuropathic pain signaling in dorsal horn neurons, and Huntington’s disease. This evidence concerns the gene THOP1 and early-onset autosomal dominant Alzheimer disease.