IDH2 and cancer: Cancer types that displayed the largest differences between groups were LGG (IDH1 1% in the low- versus 95% in the high-methylation group), GBM (IDH1 0% versus 88%), LAML (IDH1 6% versus 56%; IDH2 3% versus 44%) and KIRC (SETD2 0% versus 36%) (Figure 3A).