PBRM1 and cancer: The results confirmed known associations (Figure 3C), such as cancer-related genes involved in the Ras/TP53 pathway [e.g. TP53 (5/10 cancer types) and KRAS (1/10)]; genes involved in chromatin remodeling by the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex [e.g. ATRX (2/10) and ARID1A, PBRM1 (1/10 each)] and genes previously associated with CIMP [e.g. BAP1 (2/10)].