For example, we found that adapter molecule crk (CRK), TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) and interleukin-1 receptor-associated kinase 4 (IRAK4) are involved in the HIV-1 infection in the Kyoto Encyclopedia of Genes and Genomes (KEGG) database [109] but were not included in the HHID [44]. The gene discussed is TAB1; the disease is HIV-1 infection.