Here we show that increased numbers of CD68+ myeloid cells are CADM1+ in pancreata of aAb+ individuals and of individuals with T1D, compared with the pancreata of individuals without diabetes, and these cells are adjacent to CD8+ T cells, suggesting that induction of CADM1 in macrophage or DC populations may contribute to the pathogenesis of autoimmune diabetes. This evidence concerns the gene CADM1 and diabetes mellitus.