Notably, both miR-375 and Cadm1 are also expressed in pancreatic α cells (22, 36), and although this functional interaction has not been validated in this cell type, our result showing increased colocalization of CADM1 and GCG in aAb+ and T1D pancreata may also allude to an important role for miR-375 in restricting CADM1 expression in the α cell compartment to minimize interaction with infiltrating immune cells. Here, CADM1 is linked to type 1 diabetes mellitus.