Likewise, high-resolution 3D analysis further supported (a) the increased proximity of CD8+ cells to CADM1+ cells in pancreata from the aAb+ and T1D groups compared with those from the Non group (Figure 7, A and C) as well as (b) the colocalization of CADM1+CD68+ immunoreactivity in pancreata from the aAb+ and T1D groups compared with those from the Non group (Figure 7, B and D). This evidence concerns the gene CADM1 and type 1 diabetes mellitus.