The identification of Cadm1 as a potent mediator of intercellular contact among myeloid cells from the NOD model posed a novel hypothesis for an investigation into autoimmune diabetes pathogenesis, and we next sought to determine whether CADM1 expression in these immune cells contributes to direct interactions with CD8+ T cells within the islet microenvironment during human T1D. This evidence concerns the gene CADM1 and type 1 diabetes mellitus.