CADM1 and type 1 diabetes mellitus: Together, these results demonstrate that in addition to the increased number CD68+ cells present in the islet microenvironment in aAb+ and T1D pancreata, the increased colocalization of CADM1 and CD68 can reflect either increased CADM1 expression or the increase in the number of CADM1+CD68+ cells (Figure 4E).