Consistent with these observations, numbers of peri-islet CADM1+CD68+ myeloid cells adjacent to CD8+ T cells were also increased in pancreatic sections from individuals with T1D and those who were aAb+, compared with the Non group, indicating CADM1-mediated cell-cell contact may facilitate cytotoxic T lymphocyte (CTL) infiltration during autoimmune diabetes pathogenesis. The gene discussed is CD8A; the disease is type 1 diabetes mellitus.