Expressions of inflammatory cytokines in the glomeruli were assessed and showed that diabetes elevated the expressions of Ccl2, Tnfa, Il1b, Adgre1 (F4/80), and Itgam (CD11b) in both PPKM2Tg and WT mice, but they were attenuated in diabetic PPKM2Tg mice (Figure 3F). This evidence concerns the gene CCL2 and diabetes mellitus.