NOS3 and diabetes mellitus: The expressions of hypoxia inducible factor 1α (Hif1a), endothelial nitric oxide synthase eNOS (Nos3), angiopoietin 1 (Angpt1), and angiopoietin 2 (Angpt2) were assessed; Nos3 and Angpt1 showed a significant decline in diabetic WT mice versus non-DM WT mice.