ADAR and glioblastoma: As ADAR1 is regulated by interferon through the JAK/STAT pathway (53, 54), we performed gene set enrichment analysis based on Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways in the GBM TCGA data set, revealing that the JAK/STAT signaling pathway was indeed one of the most differentially expressed gene sets in GBMs (Figure 7A).