There are 2 major proinflammatory actions driving hypertensive cardiovascular remodeling and hypertension: leukocyte recruitment into cardiovascular tissues followed by T cell/IL-17–driven inflammation and, simultaneously, a destabilized/reduced antiinflammatory CD4+FoxP3+ Treg/IL-10 response (6–12, 15–17). This evidence concerns the gene IL10 and Hypertension.