AGT and hypertrophic cardiomyopathy: Compared with those receiving vehicle, ANGII-infused WT mice showed typical characteristics of pathological concentric hypertrophic cardiomyopathy expressed by increase in LV wall thickness during diastole (P < 0.01; Figure 2, A, E, and F) and systole (P < 0.01; Figure 2, B, E, and F) along with decreased end-diastolic (P < 0.01; Figure 2C) and stroke volumes (P < 0.01; Figure 2D).