Here, we demonstrate that in all of our 4 mouse experimental models, EC-Del1 or DEL-1–Fc–treated, but not mutant DEL-1–RGE–Fc–treated, mice were protected from hypertension-induced cardiovascular inflammation by infiltration of fewer CD45+ leukocytes, TCR-β+, and CD45+IL-17+ leukocytes in aorta and heart. This evidence concerns the gene IL17A and hypertensive disorder.