CD8A and neoplasm: In the MC38 tumor model, mIgG2c-G400R mice also exhibited increased amounts of CD8+ T cells within subcutaneous tumor tissues (Figure 4D), and especially increased CD44hiCD62LloCD8+ effector T cells (Figure 4E), with elevated levels of cytolytic IFN-γ (Figure 4F) and granzyme B production (Figure 4G), suggesting that tumor-infiltrating CD8+ T cells from MC38-inoculated mIgG2C-G400R mice maintain an optimal functionality that may help to limit tumor progression.