We also detected peripheral node addressin (PNAd) via IHC, a specific marker for high endothelial venules (HEVs) (36), and found increased proportions of HEV+ TLSs in the tumor specimens of hIgG1-G396R homozygous patients (Figure 5E), suggesting increased TLS formation and recruitment of lymphocytes in hIgG1-G396R homozygotes. Here, NTAN1 is linked to neoplasm.