The transcriptional levels of 5 chemokines (CXCR5, CXCL12, CXCL13, CCL19, and CCL21) that have been reported to be involved in the formation of TLSs (37) were also prominently elevated in both the tumor specimens from mIgG2c-G400R mice (Figure 5F) and hIgG1-G396R homozygous CRC patients (Figure 5G). Here, CXCL12 is linked to colorectal carcinoma.