CD8A and neoplasm: Thus, we applied CD8+ T cell depletion in WT and mIgG2c-G400R mice by anti-CD8a antibody treatment before and during MC38 tumor model induction (Supplemental Figure 7J), and found that the enhanced antitumor effect of mIgG2c-G400R mice does depend on the normal function of CD8+ T cells to some extent (Supplemental Figure 7K).