IGHG3 and infectious otitis media: Consistently, the levels of intestinal IgG2c antibodies were significantly increased in the colon explants of mIgG2c-G400R mice upon AOM/DSS induction, while the levels of intestinal IgA, IgG1, IgG2b, and IgG3 antibodies in mIgG2c-G400R mice were comparable to WT mice (Figure 6F).