Nevertheless, in hIgG1-G396R carriers, there were increased proportions of IgG+ plasma cells, CXCR5+ T follicular helper cells, CD6+ tumor-resident memory T cells, and decreased proportions of LAYN+ exhausted T cells (Supplemental Figure 7D), implying that the variant favors the formation of an antitumor microenvironment. This evidence concerns the gene CXCR5 and neoplasm.