As we observed elevated CD8+ T cell infiltration and activation in hIgG1-G396R homozygotes and CD8+ T cells are one of the key tumor cytotoxic effector cells in antitumor immunity, we therefore supposed that CD8+ T cells might be essential for protective effects in antitumor responses conferred by hIgG1-G396R. This evidence concerns the gene CD8A and neoplasm.