PPARA and obesity due to melanocortin 4 receptor deficiency: In diabetes and obesity,PPAR-α is a target for controlling glycemia and metabolic dysregulation,65,66 and miR-122 can regulate PPAR-α.67 Therefore, we measured the effect of γP-122-I on hepatic PPAR-αand found that it decreases the HFD-induced PPAR-α upregulationin the HFD-fed mice (Figure S3C).