In the non-HF group, no significant changes in E/E′ ratio (11.0 ± 1.5 vs. 11.6 ± 2.1; P = 0.44) or NT-proBNP levels (166 ± 117 vs. 153 ± 112 pg/ml; P = 0.72) were observed during the follow-up period. The gene discussed is NPPB; the disease is hydrops fetalis.