LPA and coronary artery disorder: Most notably, despite the fact that the genome-wide GRS for CAD encompasses 6.6 M SNPs, removal of the broader sense LPA locus (defined as the ≈1.76 megabases region that showed genome-wide significant hits in Mack et al17) strongly reduced the genetic CAD risk in this family, bringing most of their CAD GRS below the 95th percentile of the respective distribution in KORA F4 (Figure 3).