LPA and coronary artery disorder: All 3 SNP have been reported by several GWAS studies on Lp(a), dyslipidemias, CAD risk, and related phenotypes.32 An overly strongly expressed 21 KIV allele of the LPA locus, carrying a high load of Lp(a)-increasing variants might thus suffice as primary cause for the hyper-Lp(a) phenotype in this family.