Hypothesizing that the role of Lp(a) in determining the CAD risk may be further modified by an unfavorable polygenic background, we quantified the genome-wide polygenic contribution to CAD risk using a recently published genomic CAD GRS.29 All CAD cases but one showed CAD GRS above the 97.5th percentile of the score distribution in KORA F4. This evidence concerns the gene LPA and coronary artery disorder.