KCND2 and chronic kidney disease: Surprisingly, the results of Western blot showed that Ito,f-related proteins (Kv4.2, Kv4.3, and KChIP2) in the heart of CKD rats were significantly lower than those in the sham group (Figure 1, G and H), and the results of IHC also showed that Kv4.2 and Kv4.3 were downregulated in the heart of CKD rats compared with sham group (Figure 1J).