Importantly, their absence does not appear to modify virus entry in LILRB4-expressing myeloid cells (Figure 3B) despite resulting in increased levels of Src homology region 2 domain-containing phosphatase 1 (SHP-1) phosphorylation (Supplemental Figure 11), suggesting that the role of LILRB4 role in viral infection is linked to their immunomodulatory activity and not to increased viral entry. Here, LILRB4 is linked to viral infectious disease.