As shown in Figure 3A and Supplemental Figure 4A, purified mouse LILRB4 (mLILRB4) proteins, as well as human LILRB4 (hLILRB4) proteins, bind to ZIKV directly in a dose-dependent manner, whereas LILRA5 does not, suggesting that LILRB4 could directly modulate viral infection of cells. Here, LILRA5 is linked to viral infectious disease.