However, as shown in Figure 3B, bone marrow–derived macrophages (BMDMs) from naive WT and LILRB4-KO mice were infected with pHrodo-labeled ZIKV to similar degrees, and overexpression of LILRB4 did not enhance ZIKV infection (Supplemental Figure 4B), suggesting that although LILRB4 binds ZIKV, its expression does not directly modulate ZIKV entry or replication. Here, LILRB4 is linked to Zika virus infectious disease.