Although MP FRET substrates, similar to endogenous MP substrates, are generally cleaved by multiple closely related proteases (51), and thus not all enzymatic activity detected is attributable to ADAM8, tracking of proteolytic activities in lung fluids using a fluorescent substrate that covers ADAM8 activity could be a useful tool to rapidly monitor and stratify ARDS patients. The gene discussed is ADAM8; the disease is acute respiratory distress syndrome.