ADAM8 and acute respiratory distress syndrome: To this end, we selected PEPDab013 as the FRET peptide mostly specific for ADAM8, which is based on the ADAM8 cleavage site in CD23 (Supplemental Figure 9, A and B) (37, 52) and measured breakdown of this substrate by real-time fluorescence increase in BAL samples of patients with and without ARDS from pneumonia.