TP53 and acute myeloid leukemia: Further, all of the p53-intact AML patients with mLOY had significant downregulation of the HALLMARK_p53 pathway compared with those without mLOY (TCGA LAML, NES = –1.82, P = 0.00; BEAT AML, NES = –1.33, P = 0.01) (Supplemental Figure 3, C and D).