TNF and Nephropathy: Experimental studies have found that Triptolide has shown good anti-inflammatory and immunosuppressive effects in the treatment of many diseases and verified that Triptolide can attenuate inflammatory response, lung injury, and kidney damage in multiple autoimmune diseases by inhibiting NF-κB, vascular cell adhesion molecule-1, IL-1, IL-6, IL-17, and TNF-α, through interfering NF-κB [10,52], PI3K-AKT-mTOR, and apoptosis signal pathway et al.