Hyperthermia is the operation of heating the tumor‐loaded tissue to 41–46 °C,[12] which has been successfully utilized as an “adjuvant” for improving the efficacy of chemotherapy, radiotherapy and ferroptosis therapy with little influence on surrounding normal tissues during treatment.[13] More importantly, hyperthermia is closely related with the ICD induction, owing to the capability of causing endoplasmic reticulum (ER) stress,[14] which partly results in the calreticulin exposure to the outer plasma membrane (ecto‐CRT, a key marker of ICD). This evidence concerns the gene CALR and neoplasm.